This post is dedicated to a good friend who has been my comrade in wellness-oriented life-choices. Many months ago, he asked me to investigate a substance called
TA-65 which is reported to actually lengthen
telomeres. Telomeres are at the ends of
chromosomes, which are long strings of genes (DNA) that encode each cell's machinery. A human is composed ~ 10 trillion cells! Each time a cell divides, the telomeres become shorter. There is a correlation between telomere length and healthy heart & immune system. Some
researchers even believe telomere manipulation will help cure cancer.
 |
| Astragalus membranaceus |
The compound TA-65 and a related molecule
TAT2 (Cycloastragenol) are isolated from the root of the Chinese herbal remedy
Astragalus membranaceus which has been in use for over 2,000 years to increase metabolism, promote healing and enhance the immune system.
Looking at the molecular structures, I see a structural similarity to the endogenous hormone estrogen (Estradiol). The difference between TA-65 (proprietary structure I found through SciFinder) and TAT2 (discovered on Wikipedia) seems to be glycoconjugation. I have not had enough time to read up on the mechanism of action of these molecules, more reading for another day no doubt!
 |
| From SciFinder (TA-65) and Wikipedia (Cycloastragenol, Estradiol) |
As far as the fountain of youth goes, I think the telomere shortening over time is part of life. To partake of herbal remedies is fine, but to believe we can stop the clock on aging is a myth that has flourished since the 5th century BC. Although it is great fodder for art (Eduard Vieth, a Viennese painter who worked around the turn of the 20th century AD) it is probably not a good thing to tamper with.
Human cells that were taken from an 89 year old man were made very very young again, in form and function in the late 1990s by Geron corporation and they never aged again and were immortals, just with telomerase production being stimulated.
ReplyDeleteHarvard reversed the ages of mice so old the were close to death in 2010, to a very youthful state with just 30 days of telomerase activation.
2011 Mayo erased the signs of aging twice in mice just by getting rid of the short telomered senescent cells in them.
TA65 has been shown in studies to induce telomerase in cells, and to reduce the short telomered cell counts over months of taking it in published studies.
For more info and info on humans taking it check out Dr Park MD MPH and his patients and observed changes while taking TA65 where there is a ton of info.
http://www.youtube.com/user/drpark65
don't knock cycloastragenol 'til you try it. just cause its expensive is not a excuse to be biasly negative since it will cost you too much! you said the compound looks similar to estrogen and it kinda does but trust me, it has given me nice, lean, shapely, hard muscles than I ever had without ever working out. something to do with naturally effect human growth factor or something. I do take 5mg ones every 3hrs though. I also take alot of b-vitamins, enzymes, minerals, krill oil, co q10, protein shakes etc but after doing cycloastragenol for 5 months to see what it did to my body and then noticing the results diminishing after 2 months not doing cycloastragenol, I had to get back on it. I also heard its a good adaptagen too. just look more into it.
ReplyDelete