Monday, October 19, 2009
Road Rash => Rest Day
What happened? Well I'm still not sure, crashes happen really fast. What's going through my mind right now is (1) I ran 10 miles the day before and didn't get more than 5 hours sleep two nights in a row and worked long hours all week and I have slow reflexes even on a good day and therefore the bottom line is that I messed up (2) I got new tires and new brakes and this was my first ride after two major mechanical changes to my vehicle so the bike was to blame. The sweethearts I ride with keep offering to take the blame for me going down, but I'm just glad that I didn't take anyone else out. There is no ride worth going on if you injure yourself or someone else. I should have taken it easier that day.
What are my goals? Why put my body through this torture? What am I proving? And to whom? All these are great questions. The truth is that I don't know. I know I'm doing what feels good and right now I am training heavily. I enjoy the views and the outdoors and it brings me a warm and fuzzy feeling that lasts about a day-and-a-half. Which is coincidentially about as long as it takes for the pain from the exertion to fully hit my muscles. About the fourth day without a workout, I start to twitch and feel a pain in my muscles from not doing anything. If I go five or more days, I start to get really crabby at work and at home.
I just read a great article about how exercise can raise the baseline levels of both norepinephrine and dopamine. I think that's what I'm benefiting from. I know that without it I'm suffering. Everyone around me sees it, but I must endure. Luckily the cycling helps.
Monday, October 5, 2009
In the Interim
Tuesday, August 4, 2009
I Don't Like the Drugs (But the Drugs Like Me)
Don't get the wrong impression, if you were my neighbor, you might think because there are always a lot of people going in and out of my apartment and staying up late talking, that we do nothing but "party."
The truth is that most of these friends are fellow scientists, studying some aspect of drugs and hoping someday to be employed by a drug company. For example, my biking friend Andrew is singlehandedly making drugs and determining their bioactivity. My good friend Homero studies the toxicicity of drugs by observing DNA damage as a function of drug dose. And I am searching for "natural products," drugs made naturally by plants.
As for me, I used to avoid taking drugs. Something about my upbringing told me that you shouldn't need to rely on external agents to "feel better." I guess that I would say now that pain which prevents you from getting out of bed is a sufficient reason to take drugs. I still tend to take the minimum dose.
The first drug I became comfortable with was Naproxen (available over-the-counter as Aleve). It was prescribed to me after a back injury. I found that it was non-addictive and effective at reducing my pain and inflammation. Those were the ballet days.
Of course when I had a fever, I was given Tylenol (paracetemol, acetomenophen) or Aspirin (acetylsalicylic acid). Other aches and pains, including my Mom's headaches, were treated with Motrin or Advil (ibuprofen).
All of these drugs are in the same class, non-steriodal anti-inflammatory drugs (NSAIDs), which shut down the body's inflammatory signaling pathway. Because each molecular structure is slightly different, each of these drugs has a slightly different interaction with their "target" protein, cyclooxygenase (COX). Looking at their structures below, it is easy to imagine how they could "fit" into a "pocket" created by a much larger molecule. COX is about 350 times more massive than any of these "small molecule" drugs.

I stuck with non-addictive drugs until I discovered caffeine. ( : Maybe in future blogs I can discuss caffeine and other adenosine receptor antagonists. Other classes of drugs I would like to write about are histamine antagonists and seratonin reuptake inhibitors. Future blog topics of a scientific nature may be on the new wave of "biologics," as recently featured in Chemical & Engineering News, which are the newest revolution in drug development. I found it an engaging topic on a personal level because the article really highlighted the cultural divide between traditional "small molecule" chemists in pharma and those trained in molecular biology and bioanalytical chemistry who are equipped to produce and characterize protein-based drugs.
Saturday, July 25, 2009
My First Time Trial

Sunday, July 19, 2009
Life Lessons
(1) wanting to do something and being motivated/committed enough to finish it are 2 different things
(2) you have to take/ask for advice from people older and more experienced than you, your survival depends on it
(3) setting unrealistic goals doesn't do anyone any good
(4) a positive mental outlook is your most valuable asset
(5) each teammember should operate both independently and interconnectedly at all times, both autonomy/independence and communication/interreliance are important for team success
(6) "the price of success is hard work, dedication to the job at hand, and the determination that whether we win or lose, we have applied the best of ourselves to the task at hand." - Vince Lombardi
I know I had some other good revelations but I didn't have a pen/paper to write them as I was riding and I was so focused on "Stayin' Alive" that I didn't have the brainpower to really remember.
I'm showing below the elevation profile, which you can see is relatively flat (1% grade at most). I've labeled some of the parts I remember most vividly.
(A) 6:45am, mile 11, When Cliff went down and bloodied his knee up, Edith and I taped a Maxi Pad to it
(B) 7:40am, mile 22, A second group joined us at the Corona West Metrolink station
(C) 8:20am, mile 29, A third group joined us at Featherly Park (see picture on Facebook)
(D) 9:13am, mile 42, Angel's Stadium/Honda Center, almost to the OCEAN!!! (see picture)
(W) 9:58am, mile 56, my first fiew of the pacific. (see pictures)
(E) 1:40pm, mile 84, The HOT part of the day (103 deg F), we took a 15 min shade break (a non-scheduled stop)
(F) ???, mile 92, The BIG HILL which was to me the most brutal part of the ride, after which I couldn't cool my body down at all. Luckily, my friend Tom told me to squirt myself with water and that helped immensely
(G) ???, mile 100, The Farmer Boys rest stop (also non-scheduled) where we sat inside in a wonderfully comfortable and AIR CONDITIONED building drinking ice water and eating beef jerky
(H) ???, mile 106, The last painful stretch where I also could not stay cool. I used almost all the water we picked up at Farmer Boys just to douse my arms and legs repeatedly
We got back to Mission Burger in downtown Riverside at ~4:30pm. At the time I felt I could have gone further but definitely did not want to face any more hills or heat.
Pictures: http://www.facebook.com/album.php?aid=91961&id=660124126&l=bfe7d29b93
Friday, July 17, 2009
My first CENTURY is tomorrow!
Well, since this is a blog about biking, it would be unfortunate if I didn't write about how I'm feeling right now, the day before I do my first century. Why am I nervous? Well I think it's because I'm afraid I won't be able to finish. Or maybe I will finish and then I'll scare myself at how tough I've become. Or maybe I'll end up in the hospital because I'll finish but I will seriously injure myself in the process. See how MY MIND SPINS around every possibility?